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2010 1
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2023 12
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Darwin, MSI2, and relapse in T-ALL.
Barata JT. Barata JT. Blood. 2024 Jan 25;143(4):294-296. doi: 10.1182/blood.2023022490. Blood. 2024. PMID: 38270944 No abstract available.
Roles for MSI2 and PROX1 in hematopoietic stem cell activity.
Hope KJ, Sauvageau G. Hope KJ, et al. Curr Opin Hematol. 2011 Jul;18(4):203-7. doi: 10.1097/MOH.0b013e328347888a. Curr Opin Hematol. 2011. PMID: 21577104 Review.
Regulatory control imposed by MSI2 may be achieved partly through regulation of the Notch signaling pathway. ...PROX1 functions as a tumor suppressor in numerous tissue types and has been found mutated in hematopoietic cell lines and primary blood malignancies. SUMM …
Regulatory control imposed by MSI2 may be achieved partly through regulation of the Notch signaling pathway. ...PROX1 functions as a …
Stem Cells, Cancer, and MUSASHI in Blood and Guts.
Kharas MG, Lengner CJ. Kharas MG, et al. Trends Cancer. 2017 May;3(5):347-356. doi: 10.1016/j.trecan.2017.03.007. Epub 2017 Apr 8. Trends Cancer. 2017. PMID: 28718412 Free PMC article. Review.
The mammalian MSI family of RNA-binding proteins (RBPs) have important roles as oncoproteins in an array of tumor types, including leukemias, glioblastomas, and pancreatic, breast, lung, and colorectal cancers. The mammalian Msi genes, Msi1 and Msi2, have been most thoroug …
The mammalian MSI family of RNA-binding proteins (RBPs) have important roles as oncoproteins in an array of tumor types, including leukemias …
Cancer progression by reprogrammed BCAA metabolism in myeloid leukaemia.
Hattori A, Tsunoda M, Konuma T, Kobayashi M, Nagy T, Glushka J, Tayyari F, McSkimming D, Kannan N, Tojo A, Edison AS, Ito T. Hattori A, et al. Nature. 2017 May 25;545(7655):500-504. doi: 10.1038/nature22314. Epub 2017 May 17. Nature. 2017. PMID: 28514443 Free PMC article.
MSI2 is physically associated with the BCAT1 transcript and positively regulates its protein expression in leukaemia. Taken together, this work reveals that altered BCAA metabolism activated through the MSI2-BCAT1 axis drives cancer progression in myeloid leukaemia. …
MSI2 is physically associated with the BCAT1 transcript and positively regulates its protein expression in leukaemia. Taken together, …
MSI2 deficiency in ILC3s attenuates DSS-induced colitis by affecting the intestinal microbiota.
Li N, Xu S, Zhang S, Zhu Q, Meng X, An W, Fu B, Zhong M, Yang Y, Lin Z, Liu X, Xia J, Wang J, You T, Yan C, Tang H, Zhuang G, Peng Z. Li N, et al. Front Immunol. 2023 Jan 12;13:963379. doi: 10.3389/fimmu.2022.963379. eCollection 2022. Front Immunol. 2023. PMID: 36713428 Free PMC article.
METHODS: Msi2(flox/flox) mice (Msi2(fl/fl) ) and Msi2(flox/flox)Rorc(Cre) mice (Msi2(deltaRorc) ) were induced by DSS to establish the IBD model. ...RESULTS: MSI2 was knocked out in the ILC3s of Msi2(deltaRorc) mice. The Msi2(delta …
METHODS: Msi2(flox/flox) mice (Msi2(fl/fl) ) and Msi2(flox/flox)Rorc(Cre) mice (Msi2(deltaRorc) ) were induced b …
Clonal evolution dissection reveals that a high MSI2 level promotes chemoresistance in T-cell acute lymphoblastic leukemia.
Zhang J, Duan Y, Wu P, Chang Y, Wang Y, Hu T, Liu C, Chen X, Zong S, Chen X, Wu Y, Jin L, Lan Y, Liu X, Cheng X, Ding F, Li T, Chen X, Guo Y, Chen Y, Yang W, Zhang L, Zou Y, Cheng T, Zhu X, Zhang Y. Zhang J, et al. Blood. 2024 Jan 25;143(4):320-335. doi: 10.1182/blood.2023020490. Blood. 2024. PMID: 37801708
Analysis of commonly enriched drifted gene signatures showed expression of the RNA-binding protein MSI2 was significantly upregulated in the persistent TCR clonotypes at relapse. Integrated in vitro and in vivo functional studies suggested that MSI2 contributed to t …
Analysis of commonly enriched drifted gene signatures showed expression of the RNA-binding protein MSI2 was significantly upregulated …
Differential DNA methylation of MSI2 and its correlation with diabetic traits.
Jeon JP, Koh IU, Choi NH, Kim BJ, Han BG, Lee S. Jeon JP, et al. PLoS One. 2017 May 24;12(5):e0177406. doi: 10.1371/journal.pone.0177406. eCollection 2017. PLoS One. 2017. PMID: 28542303 Free PMC article.
Among them, three CpG sites were overlapped; they were mapped to the MSI2 and CXXC4 genes. In a DNA methylation replication study done by pyrosequencing (n = 440), the CpG site of MSI2 were shown to have strong associations with the T2D group (p value = 2.20E-16). . …
Among them, three CpG sites were overlapped; they were mapped to the MSI2 and CXXC4 genes. In a DNA methylation replication study don …
Musashi-2 (MSI2) regulates epidermal growth factor receptor (EGFR) expression and response to EGFR inhibitors in EGFR-mutated non-small cell lung cancer (NSCLC).
Makhov P, Bychkov I, Faezov B, Deneka A, Kudinov A, Nicolas E, Brebion R, Avril E, Cai KQ, Kharin LV, Voloshin M, Frantsiyants E, Karnaukhov N, Kit OI, Topchu I, Fazliyeva R, Nikonova AS, Serebriiskii IG, Borghaei H, Edelman M, Dulaimi E, Golemis EA, Boumber Y. Makhov P, et al. Oncogenesis. 2021 Mar 15;10(3):29. doi: 10.1038/s41389-021-00317-y. Oncogenesis. 2021. PMID: 33723247 Free PMC article.
We evaluated the mechanism of MSI2 action in NSCLC to gain therapeutically useful insights. Reverse phase protein array (RPPA) analysis of MSI2-depleted versus control Kras(LA1/+); Trp53(R172HdeltaG/+) NSCLC cell lines identified EGFR as a MSI2-regulated prot …
We evaluated the mechanism of MSI2 action in NSCLC to gain therapeutically useful insights. Reverse phase protein array (RPPA) analys …
Transcriptome-wide analysis uncovers the targets of the RNA-binding protein MSI2 and effects of MSI2's RNA-binding activity on IL-6 signaling.
Duggimpudi S, Kloetgen A, Maney SK, Münch PC, Hezaveh K, Shaykhalishahi H, Hoyer W, McHardy AC, Lang PA, Borkhardt A, Hoell JI. Duggimpudi S, et al. J Biol Chem. 2018 Oct 5;293(40):15359-15369. doi: 10.1074/jbc.RA118.002243. Epub 2018 Aug 20. J Biol Chem. 2018. PMID: 30126842 Free PMC article.
To better understand the function of MSI2 in leukemia, the mRNA targets that are bound and regulated by MSI2 and their MSI2-binding motifs need to be identified. ...In summary, we have identified multiple MSI2-regulated mRNAs and provided evidence that …
To better understand the function of MSI2 in leukemia, the mRNA targets that are bound and regulated by MSI2 and their MSI2 …
Tumorigenic role of Musashi-2 in aggressive mantle cell lymphoma.
Sureda-Gómez M, Balsas P, Rodríguez ML, Nadeu F, De Bolòs A, Eguileor Á, Kulis M, Castellano G, López C, Giné E, Demajo S, Jares P, Martín-Subero JI, Beà S, Campo E, Amador V. Sureda-Gómez M, et al. Leukemia. 2023 Feb;37(2):408-421. doi: 10.1038/s41375-022-01776-x. Epub 2022 Dec 12. Leukemia. 2023. PMID: 36509891 Free PMC article.
SOX11 is directly bound to the MSI2 promoter upregulating its expression in vitro. MSI2 intronic enhancers were strongly activated in SOX11+ MCL cell lines and primary cases. MSI2 upregulation was significantly associated with poor overall survival independen …
SOX11 is directly bound to the MSI2 promoter upregulating its expression in vitro. MSI2 intronic enhancers were strongly activ …
54 results